For laboratory research only · Not for human or veterinary use

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A 10 mg MOTS-c vial: clear glass with a silver crimped cap, labelled MOTS-C 10MG, peptide research, research use only.
Lot NVE-2429-AVerified

MOTS-c

Mitochondrial ORF of the 12S rRNA type-c

Each vial contains 10 mg of MOTS-c.

MOTS-c is a mitochondrial-derived peptide, encoded in mitochondrial DNA rather than in the nucleus, and one of the few known. Cell and rodent work covers mitochondrial-to-nuclear signalling, AMPK, and glucose and fatty-acid handling, including diet-induced obesity and exercise models. Human studies have measured it as a circulating marker in ageing and around exercise, without testing it as an intervention.

  • Peptide, 16 amino acids
  • Lyophilized powder, requires reconstitution
Vial size

Price

$60.00 CAD

In stock

Produced & shipped in Canada

Specification

CAS number
1627580-64-6
Molecular formula
C101H152N28O22S2
Molecular weight
2,174.6 g/mol
Sequence
MRWQEMGYIFYPRKLR
Purity
≥ 98.6% by RP-HPLC
Form
Lyophilized powder
Third-party assay
Purity, fill and endotoxin
Origin
Canada
Storage
-20 °C, protected from light
Lot
NVE-2429-A

How it works

Where the peptide is encoded is what sets the research question. A sequence written in mitochondrial DNA is studied as a signal travelling outwards to the nucleus, and what cell and rodent work measured while that signal was present is the subject of everything below — not energy in a person.

  • Mitochondrial-to-nuclear signalling

    Where it was characterised

    Encoded in the mitochondrial 12S rRNA region and studied as a retrograde signal from the mitochondrion to nuclear gene expression. That origin is why it is studied on its own terms rather than as another nuclear-encoded peptide.

  • AMPK and nutrient handling

    Pathways in the cell work

    Cell and rodent studies of AMPK signalling and of glucose and fatty-acid metabolism. This is the bulk of the metabolic literature, and it is work in models, not a finding about anybody’s energy use.

  • Metabolic stress models

    What the animal work used

    Diet-induced obesity and exercise models in rodents, measuring how those metabolic insults were handled when the peptide was present. Adaptation in a mouse is not adaptation in a person.

  • Circulating marker in humans

    What the human work actually is

    Human studies have measured MOTS-c in blood in ageing and around exercise, as a marker. They have not tested the peptide as an intervention, so exercise capacity and recovery are not findings this page can carry.

Where the evidence stands

Preclinical. No controlled human efficacy trials have been published. Not approved as a medicine.

Working-solution calculator

Laboratory results

Opened as the laboratory issued them, unedited. Every certificate we publish

Research use only

Supplied as a laboratory research chemical. Not a drug, food or cosmetic, and not for human or veterinary use. No application guidance is provided or implied.

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